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Article

Genetic architecture of natural variation of cardiac performance from flies to humans.

eLife - 16 Nov 2022

Saha Saswati, Spinelli Lionel, Castro Mondragon Jaime A, Kervadec Anaïs, Lynott Michaela, Kremmer Laurent, Roder Laurence, Krifa Sallouha, Torres Magali, Brun Christine, Vogler Georg, Bodmer Rolf, Colas Alexandre R, Ocorr Karen, Perrin Laurent

Abstract excerpt

Deciphering the genetic architecture of human cardiac disorders is of fundamental importance but their underlying complexity is a major hurdle. We investigated the natural variation of cardiac performance in the sequenced inbred lines of the Drosophila Genetic Reference Panel (DGRP). Genome-wide associations studies (GWAS) identified genetic networks associated with natural variation of cardiac traits which were...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 36383075
DOI: 10.7554/eLife.82459
PMCID: PMC9668334

Genes

EGR2
PAX9

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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