Brugada syndrome in Japan and Europe: a genome-wide association study reveals shared genetic architecture and new risk loci.

doi:10.1093/eurheartj/ehae251

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Brugada syndrome in Japan and Europe: a genome-wide association study reveals shared genetic architecture and new risk loci.

European heart journal - 9 Jul 2024

Ishikawa Taisuke, Masuda Tatsuo, Hachiya Tsuyoshi, Dina Christian, Simonet Floriane, Nagata Yuki, Tanck Michael W T, Sonehara Kyuto, Glinge Charlotte, Tadros Rafik, Khongphatthanayothin Apichai, Lu Tzu-Pin, Higuchi Chihiro, Nakajima Tadashi, Hayashi Kenshi, Aizawa Yoshiyasu, Nakano Yukiko, Nogami Akihiko, Morita Hiroshi, Ohno Seiko, Aiba Takeshi, Krijger Juárez Christian, Mauleekoonphairoj John, Poovorawan Yong, Gourraud Jean-Baptiste, Shimizu Wataru, Probst Vincent, Horie Minoru, Wilde Arthur A M, Redon Richard, Juang Jyh-Ming Jimmy, Nademanee Koonlawee, Bezzina Connie R, Barc Julien, Tanaka Toshihiro, Okada Yukinori, Schott Jean-Jacques, Makita Naomasa

Abstract excerpt

BACKGROUND AND AIMS: Brugada syndrome (BrS) is an inherited arrhythmia with a higher disease prevalence and more lethal arrhythmic events in Asians than in Europeans. Genome-wide association studies (GWAS) have revealed its polygenic architecture mainly in European populations. The aim of this study was to identify novel BrS-associated loci and to compare allelic effects across ancestries. METHODS: A GWAS was...

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PMID: 38747976
DOI: 10.1093/eurheartj/ehae251

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