Article

Automation of 3D Liver Spheroid generation and Acetaminophen dose– response on the MO:BOT enhances assay robustness and precision

2026-03-24

Abstract excerpt

<title>Abstract</title> <p> Toxicity is a major cause of drug failure and post-marketing withdrawals, making sensitive and reproducible toxicity readouts essential for modern drug development. FDA Modernization Act 3.0 and related strategic roadmaps explicitly encourage the use of human-relevant in vitro models as New Approach Methodologies (NAMs) as an alternative to animal models. Yet, current preclinical drug...

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Literature Corpus work: 4e2728a8-9e05-5eef-aae3-0f1b9442ce9a
DOI: 10.21203/rs.3.rs-9116861/v1

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