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Article

A PET imaging agent for evaluating PARP-1 expression in ovarian cancer

6 Mar 2018

Abstract excerpt

BACKGROUND: Poly(ADP-ribose) polymerase (PARP) inhibitors are effective in a broad population of patients with ovarian cancer; however, resistance caused by low enzyme expression of the drug target PARP-1 remains to be clinically evaluated in this context. We hypothesize that PARP-1 expression is variable in ovarian cancer and can be quantified in primary and metastatic disease using a novel PET imaging agent....

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PMID: 29509546
DOI: 10.1172/jci97992

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