Article

Exploring MAPT-containing H1 and H2 haplotypes in Parkinson’s disease across diverse populations

2025-10-19

Abstract excerpt

Variation at the 17q21.31 locus, which contains the gene encoding microtubule-associated protein tau ( MAPT ), has been associated with neurodegenerative disorders, including Parkinson’s disease (PD). This highly complex locus is characterized by two broadly defined haplotypes: H1 and the inverted H2 haplotype. While H1 has been associated with an increased PD risk and is present in all ancestry populations, H2 i...

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Literature Corpus work: 4e23a749-f1f2-52ad-a4e6-0f23f909461a
DOI: 10.1101/2025.10.17.25337033

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