Article

Genomic Taxometric Analysis of Negative Emotionality and Major Depressive Disorder Highlights a Gradient of Genetic Differentiation across the Severity Spectrum

2025-02-03

Abstract excerpt

A core question in both human genetics and medicine is whether clinical disorders represent extreme manifestations of continuous traits or categorically distinct entities with unique genetic etiologies. To address this question, we introduce Genomic Taxometric Analysis of Continuous and Case-Control data (GTACCC), a novel method for systematically evaluating continuity and differentiation of traits across the seve...

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Literature Corpus work: 4e1689ee-c19d-5834-978a-26cd123c5fb7
DOI: 10.1101/2025.01.30.25321336

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