Article
Using phenotype risk scores to enhance gene discovery for generalized anxiety disorder and posttraumatic stress disorder.
Molecular psychiatry - 1 Apr 2022
Wendt Frank R, Pathak Gita A, Deak Joseph D, De Angelis Flavio, Koller Dora, Cabrera-Mendoza Brenda, Lebovitch Dannielle S, Levey Daniel F, Stein Murray B, Kranzler Henry R, Koenen Karestan C, Gelernter Joel, Huckins Laura M, Polimanti Renato
Abstract excerpt
UK Biobank (UKB) is a key contributor in mental health genome-wide association studies (GWAS) but only ~31% of participants completed the Mental Health Questionnaire ("MHQ responders"). We predicted generalized anxiety disorder (GAD), posttraumatic stress disorder (PTSD), and major depression symptoms using elastic net regression in the ~69% of UKB participants lacking MHQ data ("MHQ non-responders";...
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