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Genetic stratification of depression by neuroticism: revisiting a diagnostic tradition

2 Oct 2019

Abstract excerpt

BACKGROUND: Major depressive disorder and neuroticism (Neu) share a large genetic basis. We sought to determine whether this shared basis could be decomposed to identify genetic factors that are specific to depression. METHODS: We analysed summary statistics from genome-wide association studies (GWAS) of depression (from the Psychiatric Genomics Consortium, 23andMe and UK Biobank) and compared them with GWAS of...

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PMID: 31576797
DOI: 10.1017/s0033291719002629

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