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Highly-sensitive reporter cell line for detection of interferon types I-III and their neutralization by antibodies

2024-06-22

Abstract excerpt

Interferons (IFNs) are a critical component of innate immune defenses and limit viral disease severity. To advance studies on IFNs and their neutralization by pathogenic autoantibodies, we generated a Renilla luciferase-based reporter cell line capable of detecting the activities of IFN-Is, IFN-II, and IFN-IIIs. The reporter cell line exhibits a 125-to 2000-fold higher sensitivity to IFNs than a commonly-used alte...

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Identifiers and source

Literature Corpus work
4e110a24-55ee-5a17-bfd6-320777ea9103
DOI
10.1101/2024.06.18.599537
Open publication

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