Article

Cell fate dynamics reconstruction identifies TPT1 and PTPRZ1 feedback loops as master regulators of differentiation in pediatric glioblastoma-immune cell networks

2023-10-05

Abstract excerpt

<h4>ABSTRACT</h4> Pediatric glioblastoma is a complex dynamical disease that is difficult to treat due to its multiple adaptive behaviors driven largely by phenotypic plasticity. Integrated data science and network theory pipelines offer novel approaches to study glioblastoma cell fate dynamics, particularly phenotypic transitions over time. Here we used various single-cell trajectory inference algorithms to infe...

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Literature Corpus work: c527c434-3f9d-5630-b251-229a2017074b
DOI: 10.1101/2023.10.03.560663

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Cell fate dynamics reconstruction identifies TPT1 and PTPRZ1 feedback loops as master regulators of differentiation in pediatric glioblastoma-immune cell networksDOI 10.1101/2023.10.03.560663Read

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