Article
Single-cell transcriptomics identifies aberrant glomerular angiogenic signalling in the early stages of WT1 kidney disease.
The Journal of pathology - 1 Oct 2024
Chandler Jennifer C, Jafree Daniyal J, Malik Saif, Pomeranz Gideon, Ball Mary, Kolatsi-Joannou Maria, Piapi Alice, Mason William J, Benest Andrew V, Bates David O, Letunovska Aleksandra, Al-Saadi Reem, Rabant Marion, Boyer Olivia, Pritchard-Jones Kathy, Winyard Paul J, Mason Andrew S, Woolf Adrian S, Waters Aoife M, Long David A
Abstract excerpt
WT1 encodes a podocyte transcription factor whose variants can cause an untreatable glomerular disease in early childhood. Although WT1 regulates many podocyte genes, it is poorly understood which of them are initiators in disease and how they subsequently influence other cell-types in the glomerulus. We hypothesised that this could be resolved using single-cell RNA sequencing (scRNA-seq) and ligand-receptor...
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