The Landscape of HNF1B Deficiency: A Syndrome Not Yet Fully Explored

Abstract excerpt

The hepatocyte nuclear factor 1β (HNF1B) gene is involved in the development of specialized epithelia of several organs during the early and late phases of embryogenesis, performing its function mainly by regulating the cell cycle and apoptosis pathways. The first pathogenic variant of HNF1B (namely, R177X) was reported in 1997 and is associated with the maturity-onset diabetes of the young. Since then, more than...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Neuroendocrine Tumor Research Advances
• Share to Pancreatic and Hepatic Oncology Research
• Share to Pancreatic function and diabetes