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Low-abundance αSyn-112 promotes αSyn-140 aggregation in vitro and forms immunoreactive deposits in Parkinson’s disease brain tissue

2026-07-09

Abstract excerpt

The aggregation of α-synuclein (αSyn) is a molecular hallmark of Parkinson’s disease (PD) and other synucleinopathies. Understanding the molecular mechanisms that determine the aggregation of this protein may thus facilitate the development of disease-modifying therapies. While αSyn is most commonly expressed as a 140-residue protein (αSyn-140), recent evidence suggests an involvement of alternatively spliced αSyn...

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Literature Corpus work
4db22a43-bf7e-5cbe-abe9-57d9d24b90b7
DOI
10.64898/2026.07.05.736591
Open publication

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Low-abundance αSyn-112 promotes αSyn-140 aggregation in vitro and forms immunoreactive deposits in Parkinson’s disease brain tissueDOI 10.64898/2026.07.05.736591
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