Article

Gut microbiome-dependent IL-1 signaling is a mediator of ACVR1 <sup>R206H</sup> -driven heterotopic ossification

2026-04-08

Abstract excerpt

Inflammatory diseases cause significant morbidity and mortality, but their pathobiology is often difficult to dissect due to complex genetic-environmental interactions. Genetic forms of heterotopic ossification, such as fibrodysplasia ossificans progressiva (FOP), reduce genetic variability, allowing careful dissection of non-genetic drivers of inflammation. While >95% of FOP patients harbor the ACVR1 R206H muta...

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Literature Corpus work: 4dad2d36-a1f5-5d13-b10c-e4cd4179a308
DOI: 10.64898/2026.04.05.716562

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