Article

The 5-LOX/COX-2 cross-over metabolite, hemiketal E <sub>2</sub> , enhances VEGFR2 activation and promotes angiogenesis

2022-05-13

Abstract excerpt

Consecutive oxygenation of arachidonic acid by 5-lipoxygenase (5-LOX) and cyclooxygenase-2 (COX-2) yields the hemiketal (HK) eicosanoids, HKE 2 and HKD 2 . HKs stimulate angiogenesis by inducing endothelial cell tubulogenesis in culture; however, how this process is regulated has not been determined. Here, we identify vascular endothelial growth factor receptor 2 (VEGFR2) as a mediator of HKE 2 -induced angioge...

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Literature Corpus work: 4d8ee88b-659e-54e8-a4a8-fe5d6210e6ee
DOI: 10.1101/2022.05.13.491890

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