Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Endothelin-1-induced prostaglandin E2-EP2, EP4 signaling regulates vascular endothelial growth factor production and ovarian carcinoma cell invasion.

The Journal of biological chemistry - 5 Nov 2004

Spinella Francesca, Rosanò Laura, Di Castro Valeriana, Natali Pier Giorgio, Bagnato Anna

Abstract excerpt

Cyclooxygenase (COX)-1- and COX-2-derived prostaglandins are implicated in the development and progression of several malignancies. We have recently demonstrated that treatment of ovarian carcinoma cells with endothelin-1 (ET-1) induces expression of both COX-1 and COX-2, which contributes to vascular endothelial growth factor (VEGF) production. In this study, we show that in HEY and OVCA 433 ovarian carcinoma...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Dinoprostone
Share to Endothelin-1

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Enzyme-Linked Immunosorbent Assay

Share to Neoplasm Invasiveness

Share to src-Family Kinases

Share to Transcriptional Activation

Share to Up-Regulation

Share to Vascular Endothelial Growth Factor A

Source

Identifiers

PMID: 15347673
DOI: 10.1074/jbc.M408584200

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Endothelin-1-induced prostaglandin E2-EP2, EP4 signaling regulates vascular endothelial growth factor production and ovarian carcinoma cell invasion.PMID 15347673Read ↗

EP4 as a Therapeutic Target for Aggressive Human Breast CancerSemantic proximity Read ↗

ANGPTL4 Induction by Prostaglandin E2 under Hypoxic Conditions Promotes Colorectal Cancer ProgressionSemantic proximity Read ↗

Endothelin-1 promotes epithelial-to-mesenchymal transition in human ovarian cancer cells.Semantic proximity Read ↗

Endothelins and hypoxia-inducible factor in cancerSemantic proximity Read ↗

hMENA is a key regulator in endothelin-1/β-arrestin1–induced invadopodial function and metastatic processSemantic proximity Read ↗

Endothelin-1 induces an angiogenic phenotype in cultured endothelial cells and stimulates neovascularization in vivo.Semantic proximity Read ↗

c-Src-dependent EGF receptor transactivation contributes to ET-1-induced COX-2 expression in brain microvascular endothelial cellsSemantic proximity Read ↗

Endothelin Receptor Blockade Inhibits Molecular Effectors of Kaposi's Sarcoma Cell Invasion and Tumor Growth in VivoSemantic proximity Read ↗

Acquisition of Chemoresistance and EMT Phenotype Is Linked with Activation of the Endothelin A Receptor Pathway in Ovarian Carcinoma CellsSemantic proximity Read ↗

The 5-LOX/COX-2 cross-over metabolite, hemiketal E <sub>2</sub> , enhances VEGFR2 activation and promotes angiogenesisSemantic proximity Read ↗

Ovarian epithelial carcinoma tyrosine phosphorylation, cell proliferation, and ezrin translocation are stimulated by interleukin 1alpha and epidermal growth factor.Semantic proximity Read ↗

Vascular endothelial growth factor induction by prostaglandin E2 in human airway smooth muscle cells is mediated by E prostanoid EP2/EP4 receptors and SP-1 transcription factor binding sites.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.