Article

Protomer Selectivity of RAF Inhibitors Within the RAS/RAF Signalosome

2022-10-27

Abstract excerpt

<title>Abstract</title> <p>RAF dimer inhibitors offer therapeutic potential in RAF- and RAS-driven cancers. The utility of such drugs is predicated on their capacity to occupy both RAF protomers in the RAS-RAF signaling complex. Here we describe a method to conditionally quantify drug-target occupancy at selected RAF protomers within an active RAS-RAF signalosome in cells. RAF target engagement can be measured in...

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Literature Corpus work: 657ef1e4-d1e4-56f3-8658-3eb0e4b39c80
DOI: 10.21203/rs.3.rs-2175742/v1

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