Article
Live-cell microscopy reveals small molecule inhibitor effects on MAPK pathway dynamics.
PloS one - 1 Jan 2011
Anderson Daniel J, Durieux Jenni K, Song Kyung, Alvarado Ryan, Jackson Peter K, Hatzivassiliou Georgia, Ludlam Mary J C
Abstract excerpt
Oncogenic mutations in the mitogen activated protein kinase (MAPK) pathway are prevalent in human tumors, making this pathway a target of drug development efforts. Recently, ATP-competitive Raf inhibitors were shown to cause MAPK pathway activation via Raf kinase priming in wild-type BRaf cells and tumors, highlighting the need for a thorough understanding of signaling in the context of small molecule kinase...
Topics
- Cell Line
- Humans
- MAP Kinase Signaling System
- Mutation
- Protein Kinase Inhibitors