Article

Platform Biological Divergence: quantifying gene-level differences between bulk and single-cell transcriptomics in breast cancer

2026-01-23

Abstract excerpt

Bulk and single-cell RNA-seq offer complementary views of tissue transcriptomes. Nevertheless, pseudo-bulk (PB) profiles derived from single-cell data often differ systematically from true bulk measurements. These discrepancies are rarely quantified at the gene level, despite their impact on downstream analyses. To investigate the PB–bulk disagreement, here we introduce, based on linear mixture models, a gene-cent...

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Literature Corpus work: 4d4cf6bd-028d-5e53-a725-41c51ec4e126
DOI: 10.64898/2026.01.22.700982

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