Article

Resolution of blood RNA signatures fails to discriminate sputum culture status after eight weeks of tuberculosis treatment

2023-11-24

Abstract excerpt

<h4>Summary</h4> <h4>Background</h4> There is concerted effort to reduce the burden of 6 months antimicrobial treatment for tuberculosis (TB). Early treatment cessation at 8 weeks is effective for most but incurs increased risk of disease relapse. We tested the hypothesis that blood RNA signatures of TB disease or C-reactive protein (CRP) measurements discriminate microbiological cure after 8 weeks of treatment, a...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 4d3cd7c7-864e-5a98-adbd-e00b3d2cd03c
DOI: 10.1101/2023.11.24.23298983

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Resolution of blood RNA signatures fails to discriminate sputum culture status after eight weeks of tuberculosis treatmentDOI 10.1101/2023.11.24.23298983Read

Blood transcriptomic signatures predict poor treatment outcomes in drug-susceptible pulmonary TB in BrazilSemantic proximity Read

Circulating Cell-Free RNA in Blood as a Host Response Biomarker for the Detection of TuberculosisSemantic proximity Read

Detection of Tuberculosis Recurrence, Diagnosis and Treatment Response by a Blood Transcriptomic Risk Signature in HIV-Infected Persons on Antiretroviral TherapySemantic proximity Read

Circulating cell-free RNA in blood as a host response biomarker for detection of tuberculosisSemantic proximity Read

Detectable Changes in The Blood Transcriptome Are Present after Two Weeks of Antituberculosis TherapySemantic proximity Read

Blood RNA biomarkers for tuberculosis screening in people living with HIV prior to anti-retroviral therapy initiation: A diagnostic accuracy studySemantic proximity Read

Concise whole blood transcriptional signatures for incipient tuberculosis: A systematic review and patient-level pooled meta-analysisSemantic proximity Read

Single-gene transcripts for subclinical TB: an individual participant data meta-analysisSemantic proximity Read

Baseline host inflammatory and transcriptional profiles associated with structural and functional recovery in drug-resistant tuberculosisSemantic proximity Read

Profiling persistent tubercule bacilli from patient sputa during therapy predicts early drug efficacySemantic proximity Read

Blood transcriptomics reveal the evolution and resolution of the immune response in tuberculosisSemantic proximity Read

A new blood-based RNA signature (R9), for monitoring effectiveness of tuberculosis treatment in a South Indian longitudinal cohortSemantic proximity Read