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Circulating cell-free RNA in blood as a host response biomarker for detection of tuberculosis

10 Jun 2024

Abstract excerpt

Tuberculosis (TB) remains a leading cause of death from an infectious disease worldwide, partly due to a lack of effective strategies to screen and triage individuals with potential TB. Whole blood RNA signatures have been tested as biomarkers for TB, but have failed to meet the World Health Organization's (WHO) optimal target product profiles (TPP). Here, we use RNA sequencing and machine-learning to investigate...

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PMID: 38858368
DOI: 10.1038/s41467-024-49245-6

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