Article

Single-gene transcripts for subclinical TB: an individual participant data meta-analysis

2024-07-07

Abstract excerpt

<h4>Background</h4> Translation of blood RNA signatures may be accelerated by identifying more parsimonious biomarkers. We tested the hypothesis that single-gene transcripts provide comparable accuracy for detection of subclinical TB to multi-gene signatures and benchmarked their clinical utility to interferon-y release assays (IGRAs). <h4>Methods</h4> We identified datasets where participants underwent RNA sampli...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: c60101e1-7ec3-5434-8f97-6ca91f87683e
DOI: 10.1101/2024.07.04.24309943

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Single-gene transcripts for subclinical TB: an individual participant data meta-analysisDOI 10.1101/2024.07.04.24309943Read

Concise whole blood transcriptional signatures for incipient tuberculosis: A systematic review and patient-level pooled meta-analysisSemantic proximity Read

Circulating Cell-Free RNA in Blood as a Host Response Biomarker for the Detection of TuberculosisSemantic proximity Read

Circulating cell-free RNA in blood as a host response biomarker for detection of tuberculosisSemantic proximity Read

Blood transcriptomic signatures for symptomatic tuberculosis in an African multicohort studySemantic proximity Read

Blood transcriptomic signatures predict poor treatment outcomes in drug-susceptible pulmonary TB in BrazilSemantic proximity Read

Prospective multicentre head-to-head validation of host blood transcriptomic biomarkers for pulmonary tuberculosis by real-time PCRSemantic proximity Read

A Novel, 5-Transcript, Whole-blood Gene-expression Signature for Tuberculosis Screening Among People Living With Human Immunodeficiency VirusSemantic proximity Read

Blood RNA biomarkers for tuberculosis screening in people living with HIV prior to anti-retroviral therapy initiation: A diagnostic accuracy studySemantic proximity Read

Gene signature discovery and systematic validation across diverse clinical cohorts for TB prognosis and response to treatmentSemantic proximity Read

Combining blood transcriptomic signatures improves the prediction of progression to tuberculosis among household contacts in BrazilSemantic proximity Read

RISK6 as a Translational Host Transcriptomic Signature for Tuberculosis Diagnosis, Treatment Monitoring, and Risk StratificationSemantic proximity Read

Resolution of blood RNA signatures fails to discriminate sputum culture status after eight weeks of tuberculosis treatmentSemantic proximity Read