Article

Blood RNA biomarkers for tuberculosis screening in people living with HIV prior to anti-retroviral therapy initiation: A diagnostic accuracy study

2023-06-04

Abstract excerpt

<h4>Background</h4> Undiagnosed tuberculosis (TB) remains a major threat for people living with HIV (PLHIV). Multiple blood transcriptomic biomarkers have shown promise for TB diagnosis. We sought to evaluate their diagnostic accuracy and clinical utility for systematic pre-antiretroviral therapy (ART) TB screening. <h4>Methods</h4> We enrolled consecutive adults referred to start ART at a community health centre...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 27b391cb-8419-540b-85fc-d6f3cc018a9e
DOI: 10.1101/2023.06.01.23290783

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Blood RNA biomarkers for tuberculosis screening in people living with HIV prior to anti-retroviral therapy initiation: A diagnostic accuracy studyDOI 10.1101/2023.06.01.23290783Read

Prospective multicentre head-to-head validation of host blood transcriptomic biomarkers for pulmonary tuberculosis by real-time PCRSemantic proximity Read

Systematic review of diagnostic and prognostic host blood transcriptomic signatures of tuberculosis disease in people living with HIVSemantic proximity Read

Circulating cell-free RNA in blood as a host response biomarker for detection of tuberculosisSemantic proximity Read

A Novel, 5-Transcript, Whole-blood Gene-expression Signature for Tuberculosis Screening Among People Living With Human Immunodeficiency VirusSemantic proximity Read

Circulating Cell-Free RNA in Blood as a Host Response Biomarker for the Detection of TuberculosisSemantic proximity Read

Blood transcriptomic signatures for symptomatic tuberculosis in an African multicohort studySemantic proximity Read

Combining blood transcriptomic signatures improves the prediction of progression to tuberculosis among household contacts in BrazilSemantic proximity Read

Prospective validation of host transcriptomic biomarkers for pulmonary tuberculosis by real-time PCRSemantic proximity Read

Detection of Tuberculosis Recurrence, Diagnosis and Treatment Response by a Blood Transcriptomic Risk Signature in HIV-Infected Persons on Antiretroviral TherapySemantic proximity Read

Host Blood RNA Transcript and Protein Signatures for Sputum-Independent Diagnostics of Tuberculosis in AdultsSemantic proximity Read

Blood transcriptomic signatures predict poor treatment outcomes in drug-susceptible pulmonary TB in BrazilSemantic proximity Read

Resolution of blood RNA signatures fails to discriminate sputum culture status after eight weeks of tuberculosis treatmentSemantic proximity Read