Article

Genes used together are more likely to be fused together in evolution by mutational mechanisms: A bioinformatic test of the used-fused hypothesis

2021-08-02

Abstract excerpt

Cases of parallel or recurrent gene fusions, whether in evolution or in cancer and genetic disease, are difficult to explain, as they require multiple of the same or similar breakpoints to repeat. The used-together-fused-together hypothesis holds that genes that are used together repeatedly and persistently in a certain context are more likely than otherwise to undergo a fusion mutation in the course of evolution—...

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Literature Corpus work: 4d22a6ee-5806-5094-80e4-9fb4b96a0827
DOI: 10.1101/2021.07.31.454590

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