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Gene Duplication and Gene Fusion Are Important Drivers of Tumourigenesis during Cancer Evolution

31 Aug 2021

Abstract excerpt

Chromosomal rearrangement and genome instability are common features of cancer cells in human. Consequently, gene duplication and gene fusion events are frequently observed in human malignancies and many of the products of these events are pathogenic, representing significant drivers of tumourigenesis and cancer evolution. In certain subsets of cancers duplicated and fused genes appear to be essential for...

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PMID: 34573358
DOI: 10.3390/genes12091376

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