Article

Trisomy 21 increases microtubules and disrupts centriolar satellite localization

2021-10-26

Abstract excerpt

Trisomy 21, the cause of Down syndrome, causes a 0.5-fold protein increase of the chromosome 21-resident gene Pericentrin (PCNT) and reduces primary cilia formation and signaling. Here we investigate the mechanisms by which PCNT imbalances disrupt cilia. Using isogenic RPE-1 cells with increased chromosome 21 dosage, we find PCNT protein accumulates around the centrosome as a pericentrosomal cluster of enlarged cy...

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Literature Corpus work: 4d1f9b90-8121-5080-b4d5-3ac09699526c
DOI: 10.1101/2021.10.25.465808

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