Article

Superresolution microscopy reveals photoreceptor-specific subciliary location and function of Cep290

2020-10-28

Abstract excerpt

Mutations in the cilium-associated protein CEP290 cause retinal degeneration as part of multi-organ syndromic ciliopathies or as retina-specific diseases. The precise location and the functional roles of CEP290 within cilia and, specifically, the connecting cilia (CC) of photoreceptors, remain unclear. We used superresolution fluorescence microscopy and electron microscopy (TEM) to localize CEP290 in the CC and in...

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Literature Corpus work: 5fdfec13-3d57-57a0-ad1c-a770f86d13bb
DOI: 10.1101/2020.10.28.357806

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