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Identifying severe COVID-19 risk variants modulating enhancer reporter activity in lung cells.

PLoS genetics - 1 Jul 2026

Weykopf Giovanna, Bickmore Wendy A, Biddie Simon C, Friman Elias T

Abstract excerpt

Common genetic variants contribute to risk for complex human diseases. However, despite thousands of associations, variants modulating disease risk and their functional impact remain largely unknown. This includes SARS-CoV-2 infection, where outcomes range from asymptomatic to fatal. Most genetic risk variants associated with COVID-19 disease, identified through genome wide association studies, are located in the...

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A549 Cells
COVID-19
Enhancer Elements, Genetic
Epithelial Cells
Genes, Reporter

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Genome-Wide Association Study

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PMID: 42467704
DOI: 10.1371/journal.pgen.1012222
PMCID: PMC13399529

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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