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Article

Overexpression of HMGA1 confers radioresistance by transactivating RAD51 in cholangiocarcinoma

29 Oct 2021

Abstract excerpt

Cholangiocarcinomas (CCAs) are rare but aggressive tumors of the bile ducts. CCAs are often diagnosed at an advanced stage and respond poorly to current conventional radiotherapy and chemotherapy. High mobility group A1 (HMGA1) is an architectural transcription factor that is overexpressed in multiple malignant tumors. In this study, we showed that the expression of HMGA1 is frequently elevated in CCAs and that...

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PMID: 34716319
DOI: 10.1038/s41420-021-00721-8

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