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Article

Multi-omics-driven discovery of invasive patterns and treatment strategies in CA19-9 positive intrahepatic cholangiocarcinoma.

Journal of translational medicine - 15 Nov 2024

Ma Delin, Wei Pengcheng, Liu Hengkang, Hao Jialing, Chen Zhuomiaoyu, Chu Yingming, Li Zuyin, Shi Wenzai, Yuan Zhigao, Cheng Qian, Gao Jie, Zhu Jiye, Li Zhao

Abstract excerpt

BACKGROUND: Intrahepatic cholangiocarcinoma (ICC) is a malignant tumor with a poor prognosis, predominantly CA19-9 positive. High CA19-9 levels correlate with increased aggressiveness and worse outcomes. This study employs multi-omics analysis to reveal molecular features and identify therapeutic targets of CA19-9 positive ICC, aiming to support individualized treatment. METHODS: Data from seven clinical cohorts,...

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Share to Bile Duct Neoplasms
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Gene Expression Regulation, Neoplastic

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Source

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Identifiers

PMID: 39548460
DOI: 10.1186/s12967-024-05854-9
PMCID: PMC11568536

Genes

IDH1
KRAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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