Article

Suppression of interferon signaling via small molecule modulation of TFAM

2025-08-14

Abstract excerpt

The mitochondrial transcription factor A (TFAM) is essential for mitochondrial genome maintenance. It binds to mitochondrial DNA (mtDNA) and determines the abundance, packaging and stability of the mitochondrial genome. Because its function is tightly associated with mtDNA, TFAM has a protective role in mitochondrial diseases and supportive studies demonstrate reversal of disease phenotypes by TFAM overexpression....

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Literature Corpus work: 4cfc128a-0b4a-5583-93ab-c86ecd46a205
DOI: 10.1101/2025.08.13.670134

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