Article

AcaFinder: genome mining for anti-CRISPR associated genes

2022-08-30

Abstract excerpt

Anti-CRISPR (Acr) proteins are encoded by (pro)viruses to inhibit their host’s CRISPR-Cas systems. Genes encoding Acr and Aca (Acr associated) proteins often co-localize to form acr-aca operons. Here, we present AcaFinder as the first Aca genome mining tool. AcaFinder can: (i) predict Acas and their associated acr-aca operons using guilt-by-association (GBA); (ii) identify homologs of known Acas using an HMM (Hi...

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Literature Corpus work: 4ccbc7a7-0a55-5985-a67a-92cbb3800864
DOI: 10.1101/2022.08.29.505781

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