Article

Total cell N-glycosylation is altered during neuronal differentiation of iPSC to NSC and is disturbed by trisomy 21

2023-06-28

Abstract excerpt

<h4>ABSTRACT</h4> Down syndrome (DS) is a genetic condition caused by trisomy 21 (T21) and characterized by a range of neurological symptoms including intellectual disability, early onset of neurodegeneration and dementia, some of which can be attributed to accelerated aging. N-glycosylation is a protein modification that plays a critical role in numerous biological processes and its dysregulation is associated w...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 13a8c3b6-fd55-503e-861f-6d5643fbf0c0
DOI: 10.1101/2023.06.28.546867

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Total cell N-glycosylation is altered during neuronal differentiation of iPSC to NSC and is disturbed by trisomy 21DOI 10.1101/2023.06.28.546867Read

Accelerated biological aging in people with Down syndrome with full and segmental trisomy 21 begins in childhood as revealed by immunoglobulin G glycosylationSemantic proximity Read

The restricted N-glycome of neurons is programmed during differentiationSemantic proximity Read

Integrated analysis of glycan and RNA in single cellsSemantic proximity Read

The O-GlcNAc cycling in neurodevelopment and associated diseases.Semantic proximity Read

Analysis of genotype effects and inter-individual variability in iPSC-derived trisomy 21 neural progenitor cellsSemantic proximity Read

Neural-specific alterations in glycosphingolipid biosynthesis and cell signaling associated with two human ganglioside GM3 Synthase Deficiency variantsSemantic proximity Read

Transcriptome and Proteome Profiling of Neural Induced Pluripotent Stem Cells from Individuals with Down Syndrome Disclose Dynamic Dysregulations of Key Pathways and Cellular FunctionsSemantic proximity Read

N‐glycoproteomics reveals distinct glycosylation alterations in NGLY1 ‐deficient patient‐derived dermal fibroblastsSemantic proximity Read

An O-GlcNAc transferase pathogenic variant that affects pluripotent stem cell self-renewalSemantic proximity Read

Brief Report: Isogenic Induced Pluripotent Stem Cell Lines From an Adult With Mosaic Down Syndrome Model Accelerated Neuronal Ageing and NeurodegenerationSemantic proximity Read

Establishment of a human induced pluripotent stem cell line（SDQLCHi059-A）from a patient with congenital disorder of glycosylation carrying heterozygous mutation in MPI gene.Semantic proximity Read

Integration and comparison of multi-omics profiles of NGLY1 deficiency plasma and cellular models to identify clinically relevant molecular phenotypesSemantic proximity Read