Article

Sequential emergence and contraction of epithelial subtypes in the prenatal human choroid plexus revealed by a stem cell model

2024-06-13

Abstract excerpt

<h4>ABSTRACT</h4> Despite the major roles of choroid plexus epithelial cells (CPECs) in brain homeostasis and repair, their developmental lineage and diversity remain undefined. In simplified differentiations from human pluripotent stem cells, derived CPECs (dCPECs) displayed canonical properties and dynamic multiciliated phenotypes that interacted with Aβ uptake. Single dCPEC transcriptomes over time correlated...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 4c811537-45c2-5f7e-a100-e1cf79230714
DOI: 10.1101/2024.06.12.598747

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Sequential emergence and contraction of epithelial subtypes in the prenatal human choroid plexus revealed by a stem cell modelDOI 10.1101/2024.06.12.598747Read

Self-Organizing 3D Human Choroid Plexus-Ventricle-Cortical OrganoidsSemantic proximity Read

BMP4 Sufficiency to Induce Choroid Plexus Epithelial Fate from Embryonic Stem Cell-Derived Neuroepithelial ProgenitorsSemantic proximity Read

Single-cell multiomics atlas of organoid development uncovers longitudinal molecular programs of cellular diversification of the human cerebral cortexSemantic proximity Read

Early human fetal lung atlas reveals the temporal dynamics of epithelial cell plasticitySemantic proximity Read

Validation of non-destructive morphology-based selection of cerebral cortical organoids by paired morphological and single-cell RNA-seq analysesSemantic proximity Read

Dynamic Characterization of Structural, Molecular, and Electrophysiological Phenotypes of Human-Induced Pluripotent Stem Cell-Derived Cerebral Organoids, and Comparison with Fetal and Adult Gene Profiles.Semantic proximity Read

Temporal proteomic and PTMomic atlas of cerebral organoid developmentSemantic proximity Read

Early human fetal lung atlas reveals the temporal dynamics of epithelial cell plasticitySemantic proximity Read

Cockayne syndrome patient iPSC-derived brain organoids and neurospheres show early transcriptional dysregulation of biological processes associated with brain development and metabolismSemantic proximity Read

Modeling cerebral development <i>in vitro</i> with L- <i>MYC</i> -immortalized human neural stem cell-derived organoidsSemantic proximity Read

A subset of human choroid plexus epithelial cells exhibit mitochondrial eccentricity and distinct expression of the pigmentation-associated enzyme TYRP1Semantic proximity Read