Article

Wild Type p53 Inhibits Apoptosis Induced by bcl2 Silencing in Malignant Tumor Cells

2023-11-30

Abstract excerpt

In cancer gene therapy, anti-apoptotic gene bcl2 was one of the target to be aimed in some malignant tumor cells. Theoretically, when bcl2 expression is suppressed by siRNA technique, malignant tumor cells would undergo more apoptosis. However, in our study, different malignant tumor cells responded differently as human non-small cell carcinoma cell A549 was sensitive while cervical carcinoma cell Hela was resista...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 4c76c52c-64d3-5ff5-a131-0719e6dafab6
DOI: 10.21203/rs.3.rs-3661060/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Wild Type p53 Inhibits Apoptosis Induced by bcl2 Silencing in Malignant Tumor CellsDOI 10.21203/rs.3.rs-3661060/v1Read

Attacking cancer's Achilles heel: antagonism of anti‐apoptotic <scp>BCL</scp>‐2 family membersSemantic proximity Read

BCL-2 family proteins: regulators of cell death involved in the pathogenesis of cancer and resistance to therapy.Semantic proximity Read

BCL-2 family proteins: Regulators of cell death involved in the pathogenesis of cancer and resistance to therapySemantic proximity Read

Involvement of hTERT in apoptosis induced by interference with Bcl-2 expression and functionSemantic proximity Read

Knockdown of the Bcl-2 gene increases sensitivity to EGFR tyrosine kinase inhibitors in the H1975 lung cancer cell line harboring T790M mutation.Semantic proximity Read

Pre-existing levels of pro-survival proteins and induction of BCL-XL dictate cell fate after p53 activationSemantic proximity Read

Mutant p53 drives cancer chemotherapy resistance due to loss of function on activating transcription of PUMASemantic proximity Read

ILP-2: A New Bane and Therapeutic Target for Human CancersSemantic proximity Read

Paradoxical role of apoptosis in tumor progressionSemantic proximity Read

Human survivin is negatively regulated by wild-type p53 and participates in p53-dependent apoptotic pathwaySemantic proximity Read

Role of Bcl-2 Family Proteins in Photodynamic Therapy Mediated Cell Survival and RegulationSemantic proximity Read

Cancer cell sensitivity to bortezomib is associated with survivin expression and p53 status but not cancer cell typesSemantic proximity Read