Knockdown of the Bcl-2 gene increases sensitivity to EGFR tyrosine kinase inhibitors in the H1975 lung cancer cell line harboring T790M mutation.

doi:10.3892/ijo.2013.1895

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Article

Knockdown of the Bcl-2 gene increases sensitivity to EGFR tyrosine kinase inhibitors in the H1975 lung cancer cell line harboring T790M mutation.

International journal of oncology - 1 Jun 2013

Zou Man, Xia Shu, Zhuang Liang, Han Na, Chu Qian, Chao Tengfei, Peng Ping, Chen Yu, Gui Qi, Yu Shiying

Abstract excerpt

Epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) are being widely used as targeted therapy in non-small cell lung cancer (NSCLC), but most cases acquire drug-resistance in 9 months. However, the mechanisms of resistance are still not fully understood. Since it has been demonstrated that EGFR-TKI-mediated repression of downstream signaling cascades and apoptosis induction is a key mechanism...

Topics

Antineoplastic Agents
Apoptosis
Carcinoma, Non-Small-Cell Lung
Cell Line, Tumor
Drug Resistance, Neoplasm
ErbB Receptors
Gefitinib
Gene Knockdown Techniques
Genes, bcl-2
Humans

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Lung Neoplasms

Mutation

Protein Kinase Inhibitors

Proto-Oncogene Proteins c-akt

Proto-Oncogene Proteins c-bcl-2

Quinazolines

RNA Interference

RNA, Small Interfering

Source

Open in PubMed

Identifiers

PMID: 23588221
DOI: 10.3892/ijo.2013.1895

Genes

EGFR

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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