Role of Caveolin 1 in metabolic programming of fetal brain

Abstract excerpt

Caveolin-1 ( Cav1 ) encodes a major protein of the lipid rafts, called caveolae, which are plasma membrane invaginations found in most cells of mammals. Cav1 -null mice, at an early adult age, exhibit symptoms that are hallmarks of Alzheimer’s disease, and show brain aging similar to that of one and half year old wildtype mice. In the present study, integrative analysis of metabolomics, transcriptomics, epigenet...

Topics

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• Brain
• Methyl-CpG-Binding Protein 2
• Mice
• Mitochondrial Function and Pathology
• Mutation
• Neurons
• Pregnancy
• Rett Syndrome

Identifiers and source

Literature Corpus work

4c5908b6-d026-5b4b-b725-abe79dacb702

DOI

10.1101/2022.10.18.512714