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Article

Inheritance of perturbed methylation and metabolism caused by uterine malnutrition via oocytes

24 Feb 2023

Abstract excerpt

BACKGROUND: Undernourishment in utero has deleterious effects on the metabolism of offspring, but the mechanism of the transgenerational transmission of metabolic disorders is not well known. In the present study, we found that undernourishment in utero resulted in metabolic disorders of female F1 and F2 in mouse model. RESULTS: Undernutrition in utero induced metabolic disorders of F1 females, which was...

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PMID: 36829148
DOI: 10.1186/s12915-023-01545-x

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