Mice Undergo Organ-Specific Transcriptional and Metabolic Remodeling During Late Adolescence

Abstract excerpt

<title>Abstract</title> <p>Mouse models aimed at deciphering human aging have typically focused on early development or late-life stages. Much less is known about the transition from late adolescence to young adulthood, spanning 8 to 12 weeks of age. Here, we show that C57Bl6 mice undergo a comprehensive developmental transition characterized by significant transcriptional and metabolic reprogramming during this...

Topics

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• Age Factors
• Diet, Western
• Heart Failure
• Sex Factors
• Transcriptome
• Ventricular Dysfunction, Left
• Ventricular Function, Left
• Ventricular Remodeling

Identifiers and source

Literature Corpus work

dbd6756f-d7ae-5e87-b51a-e3932b3042da

DOI

10.21203/rs.3.rs-10171816/v1