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Article

Metabolic fingerprints of altered brain growth, osmoregulation and neurotransmission in a Rett syndrome model.

PloS one - 17 Jan 2007

Viola Angèle, Saywell Véronique, Villard Laurent, Cozzone Patrick J, Lutz Norbert W

Abstract excerpt

BACKGROUND: Rett syndrome (RS) is the leading cause of profound mental retardation of genetic origin in girls. Since RS is mostly caused by mutations in the MECP2 gene, transgenic animal models such as the Mecp2-deleted ("Mecp2-null") mouse have been employed to study neurological symptoms and brain function. However, an interdisciplinary approach drawing from chemistry, biology and neuroscience is needed to...

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Source

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Identifiers

PMID: 17237885
DOI: 10.1371/journal.pone.0000157
PMCID: PMC1766343

Genes

MECP2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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