ScISOr-ATAC reveals convergent and divergent splicing and chromatin specificities between matched cell types across cortical regions, evolution, and in Alzheimer’s Disease

Abstract excerpt

Multimodal measurements have become widespread in genomics, however measuring open chromatin accessibility and splicing simultaneously in frozen brain tissues remains unconquered. Hence, we devised Single-Cell-ISOform-RNA sequencing coupled with the Assay-for-Transposase-Accessible-Chromatin (ScISOr-ATAC). We utilized ScISOr-ATAC to assess whether chromatin and splicing alterations in the brain convergently affect...

Topics

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• Cerebral Cortex
• Chromatin
• GABAergic Neurons
• Macaca fascicularis
• Regulatory Sequences, Nucleic Acid
• Single-Cell Analysis
• Single-Cell Gene Expression Analysis
• Transcriptome

Identifiers and source

Literature Corpus work

4c3d7e36-3186-5f43-9c57-7c14bc38ad96

DOI

10.1101/2024.02.24.581897