Article

Increased chromatin accessibility mediated by nuclear factor I drives transition to androgen receptor splice variant dependence in castration-resistant prostate cancer

2024-01-12

Abstract excerpt

<h4>ABSTRACT</h4> Androgen receptor (AR) splice variants, of which ARv7 is the most common, are increased in prostate cancer (PC) that develops resistance to androgen signaling inhibitor drugs, but the extent to which these variants drive AR activity, and whether they have novel functions or dependencies, remain to be determined. We generated a subline of VCaP PC cells (VCaP16) that is resistant to the AR inhibit...

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Literature Corpus work: b4d2f0be-89dc-57a7-bfd5-97aa037461e9
DOI: 10.1101/2024.01.10.575110

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