Article

Analysis of DNA from brain tissue on stereo-EEG electrodes reveals mosaic epilepsy-related variants

2024-07-22

Abstract excerpt

Somatic mosaic variants contribute to focal epilepsy, but genetic analysis has been limited to patients with drug-resistant epilepsy (DRE) who undergo surgical resection, as the variants are mainly brain-limited. Stereoelectroencephalography (sEEG) has become part of the evaluation for many patients with focal DRE, and sEEG electrodes provide a potential source of small amounts of brain-derived DNA. We aimed to id...

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Literature Corpus work: 3c93eb94-53a1-520c-bdf5-7fa838253c18
DOI: 10.1101/2024.07.21.24310779

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