Article

A meta-analysis of chromatin-associated loci provides insights into mechanistic interpretations of trait heritability

2026-03-20

Abstract excerpt

The vast majority of trait-associated loci discovered through genome-wide association studies (GWAS) are non-coding, yet most lack statistical alignment with any discovered expression quantitative trait loci (eQTLs). In particular, eQTLs are depleted at gene-distal regions and at “functionally important” genes – those with strong selective constraint and complex regulatory landscapes – likely due to selective depl...

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Literature Corpus work: 4be8f1f9-0373-53d8-a423-802d56c51a0a
DOI: 10.64898/2026.03.19.712994

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