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Article

Epitranscriptomic Modification of MicroRNA Increases Atherosclerosis Susceptibility

2022-05-21

Abstract excerpt

Emerging evidence indicates that oxidative stress causes the hydroxylation of guanine (G) to generate 8-oxo-7,8-dihydro guanosine ( 8 OH-G) in microRNAs (miRs), which induces the guanine-to-uracil (G-to-U) transversion and thus changes the miR targetomes. However, whether and how the 8 OH-G-modified miRs are involved in vascular endothelial dysfunction and atherogenesis were unexplored. Using 8 OH-G crosslinkin...

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Literature Corpus work
4be4f815-ce99-5476-88f9-70a1564b831a
DOI
10.1101/2022.05.21.492858
Open publication

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Epitranscriptomic Modification of MicroRNA Increases Atherosclerosis SusceptibilityDOI 10.1101/2022.05.21.492858
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