Article
Heterogeneous nuclear ribonucleoprotein E1 regulates protein disulphide isomerase translation in oxidized low-density lipoprotein-activated endothelial cells.
Acta physiologica (Oxford, England) - 1 Mar 2015
Meng N, Peng N, Huang S, Wang S Q, Zhao J, Su L, Zhang Y, Zhang S, Zhao B, Miao J
Abstract excerpt
AIMS: Endothelium-derived protein disulphide isomerase (PDI) is required for thrombus formation in vivo. But, how to control PDI overproduction in oxidized low-density lipoprotein (oxLDL)-activated vascular endothelial cells (VECs) is not well understood. In this study, we try to answer this question using our newly identified activator of mTOC1 3-benzyl-5-((2-nitrophenoxy) methyl)-dihydrofuran-2 (3H)-one (3BDO)...
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