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Article

Inhibition of SDE2 Promotes Autophagy-Dependent Ferroptosis in Multiple Myeloma

2025-09-30

Abstract excerpt

<title>Abstract</title> <p><bold>Background</bold> Multiple myeloma (MM) is an incurable plasma cell malignancy with high relapse rate. Recent studies have implicated dysregulated autophagy and ferroptosis in MM progression; however, the molecular links remain elusive. This study investigated the role of SDE2, a ubiquitin-like protein overexpressed in MM, in modulating autophagy-ferroptosis crosstalk via ATG5 deg...

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Literature Corpus work
4bb4d255-0dd2-5587-b4af-90e683c290bc
DOI
10.21203/rs.3.rs-7619023/v1
Open publication

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