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Class II ferroptosis inducers are a novel therapeutic approach for t(4;14)-positive multiple myeloma

23 Jul 2024

Abstract excerpt

ABSTRACT: Multiple myeloma (MM) is a clonal plasma cell malignancy that is characterized by genetic heterogeneity. The cytogenetic abnormality t(4;14) strongly predicts poor outcome in patients with MM, even in the era of novel drugs. Ferroptosis is a new approach to antitumor therapy, but the relationship between ferroptosis and MM cytogenetic abnormalities remains largely unclear. In this study, we show that...

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PMID: 39042883
DOI: 10.1182/bloodadvances.2023010335

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