Dysregulation of DNA methylation during development as a potential mechanisms contributing to obsessive compulsive disorders and autism

Abstract excerpt

<p>Autism Spectrum Disorder (ASD) is a pervasive developmental disorder, that is raising at a concerning rate. However, underlying mechanisms are still to be discovered. Obsessions and compulsions are the most debilitating aspect of these disorders (OCD), and they are the treatment priority for patients. SAPAP3 knock out mice present a reliable mouse model for repetitive compulsive behavior and are mechanistically...

Topics

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• Angelman Syndrome
• CHARGE Syndrome
• Child Development Disorders, Pervasive
• Chromosomes, Human, Pair 15
• Megalencephaly
• Prader-Willi Syndrome
• Rett Syndrome
• Turner Syndrome

Identifiers and source

Literature Corpus work

4ba017ff-b985-5b9d-94d3-3ea69f2c7231

DOI

10.31234/osf.io/udfya