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Article

Deconvolution of pro- and antiviral genomic responses in Zika virus-infected and bystander macrophages

11 Sept 2018

Abstract excerpt

Genome-wide investigations of host–pathogen interactions are often limited by analyses of mixed populations of infected and uninfected cells, which lower sensitivity and accuracy. To overcome these obstacles and identify key mechanisms by which Zika virus (ZIKV) manipulates host responses, we developed a system that enables simultaneous characterization of genome-wide transcriptional and epigenetic changes in...

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PMID: 30206152
DOI: 10.1073/pnas.1807690115

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